Mitigation of beta 1- and/or beta 2-adrenoceptor function in human heart failure.
نویسندگان
چکیده
منابع مشابه
Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function.
Catecholamines play a central role in the regulation of energy expenditure, in part by stimulating lipid mobilization through lipolysis in fat cells. The beta-2 adrenoceptor (BAR-2) is a major lipolytic receptor in human fat cells. To determine whether known polymorphisms in codons 16, 27, and 164 of this receptor play a role in obesity and subcutaneous adipocyte BAR-2 lipolytic function, we in...
متن کاملBeta-adrenoceptor-mediated responsiveness of human internal mammary artery
The internal mammary artery (IMA) is currently the preferred conduit for myocardial revascularization. However, pre-operative vasospasm and a hypoperfusion state during maximal exercise may limit its use as a bypass graft. The mechanism of spasm has not been clearly defined. Since β-adrenoceptor activation plays a major role in vasorelaxation, the present study was carried out to investigate th...
متن کاملBeta-adrenoceptor blockers in chronic heart failure--a review.
There are now considerable clinical trial data to support the use of beta-adrenoceptor blockers in patients with chronic heart failure due to systolic left ventricular dysfunction. Increases in ejection fraction, improved well-being as judged by both patient and physician and reduced progression of ventricular dysfunction have been demonstrated. From meta-analyses of available trial data, a mor...
متن کاملGenes and acquired disease: beta-adrenoceptor polymorphisms and heart failure.
The selfish gene has little interest in the welfare of its host after reproduction. This teleological concept, albeit simplistic in the present context, may partly explain why the neuroendocrine compensatory mechanisms that have evolved for congestive cardiac failure, a condition affecting mostly older patients, are fundamentally flawed. One of these misguided compensatory responses is chronic ...
متن کاملAlterations in cardiac adrenergic terminal function and beta-adrenoceptor density in pacing-induced heart failure.
Congestive heart failure is associated with cardiac adrenergic nerve terminal changes and beta-adrenoceptor density downregulation. To study the temporal sequence of these changes, we performed studies in rabbits at 2, 4, and 8 wk of cardiac pacing (360 beats/min) and at 1, 2, and 4 wk after cessation of pacing. Rapid pacing produced left ventricular (LV) dysfunction and an increase in plasma n...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1990
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1990.tb05466.x